MyBioSource.com's PAH Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The PAH Antibody was generated using PAH, and Phenylalanine Hydroxylase as the antigen and it reacts with Human, Mouse, and Rat.
Description
Description: PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria.
Function: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin.
Subunit Structure: Homodimer and homotetramer.
Post-translational Modifications: Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine.
Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family